Episode 080: Heme Consult Series: When anticoagulation fails, Part 2

We started this conversation last week! This week, we focus on how to approach warfarin and enoxaparin failure! Be sure to check out Episode 079 for part 1!

Episode 079: Heme Consult Series: When anticoagulation fails, Part 1

It’s time for another Heme Consult series, this time focusing on another common question we see in the hospital and in clinic: “is this anticoagulation failure?”

In this two-part series, we break down how we approach the workup to determine exactly this. In this episode, we discuss "DOAC failure".

Episode 078: Management of relapsed diffuse large B-cell lymphoma (DLBCL) - part 2

In this FINAL episode of our DLBCL series, we build on our conversation from last week, focusing on the management of relapsed DLBCL. If you have not done so already, we recommend you check out Episode 077!

Episode 077: Management of relapsed diffuse large B-cell lymphoma (DLBCL) - part 1

In our last episode, we discussed our approach to primary refractory DLBCL. This week, we start our conversation about relapsed DLBCL! This is an important and complex discussion, so we have split it into two episodes to help you follow along.

If you have not done so already, we recommend you check out episode 076 for a discussion about the primary refractory setting

Episode 076: Management of primary refractory diffuse large B-cell lymphoma (DLBCL)

This week, we pick up on our discussion about management of DLBCL, focusing on the primary refractory setting. A big part of this discussion is the role of CAR-T therapy. If you have not done so already, we highly recommend you check out episode 075 for the fundamentals of CAR-T before proceeding with this episode!

Episode 075: Intro to CAR-T, Bispecifics (BiTE), and Autologous Transplant

In this week’s episode, we pause from our discussion about DLBCL to talk about the fundamentals of CAR-T, BiTE and autologous transplants, which will lay the foundation for subsequent discussions about DLBCL. These therapies are the talk of the town and have changed/will continue to change our approach to hematologic malignancies - definitely an episode you don’t want to miss.

Episode 074: Management of Advanced Stage Diffuse Large B-Cell Lymphoma (DLBCL)

In this week’s episode, we delve into the management of advanced stage DLBCL.

If you have not done so, we highly recommend you listen to our hemepath series before proceeding with this episode. Furthermore, if you have not listened to the introduction to DLBCL episode (Episode 072) or our early stage DLBCL episode (Episode 073), we highly recommend doing so, as we will be building on these basics this week.

Episode 073: Management of Early Stage Diffuse Large B-Cell Lymphoma (DLBCL)

This week, we continue our conversation about DLBCL, this time focusing our attention on the management of early stage disease.

If you have not done so, we highly recommend you listen to our hemepath series before proceeding with this episode. Furthermore, if you have not listened to the introduction to DLBCL episode (Episode 072), we highly recommend doing so, as we will be building on these basics this week.

Episode 072: Introduction to Diffuse Large B-Cell Lymphoma (DLBCL)

This week, we kick off a new series focusing on diffuse large B-cell lymphoma. In this first episode, we discuss the basics that everyone needs to understand before diving into the management of this disease.

Episode 071: Heme Consults Series: Heparin-induced thrombocytopenia (A deeper dive!)

We revisit a topic covered previously as part of our “Heme/Onc Emergencies” series: heparin-induced thrombocytopenia (HIT) in Episode 017. As part of our return, we dive deeper into the pathophysiology, principles of diagnosis, and management of HIT to help you to better understand how to approach the question of “is this HIT?” as a Hematology consultant and, more importantly, how to guide management based on your index of suspicion.

Episode 070: Heme Consults Series: Von Willebrand Disease, Part 2

This week in our hematological consultation series, we continue our discussion on von Willebrand disease (vWD), this time focusing on the type 2 subtypes and we also discuss management.

In case you missed it, we recommend checking out episode 069 for Part I of this vWD series, covering taking a bleeding history and about Type 1 and Type 3 disease.

Episode 069: Heme Consults Series: Von Willebrand Disease, Part 1

We resume our hematological consultation series with an overview of von Willebrand disease (vWD), the most common inherited bleeding disorder. In this episode, we talk about the initial steps we should take to evaluate suspected von Willebrand disease and how to differentiate the various subtypes. We will focus on vWD type 1 and 3! Be sure to tune in next week as we discuss vWD type 2 and management.

Episode 068: Breast Cancer Series, Pt. 13- Metastatic Triple Negative Breast Cancer

This week, we complete our breast cancer series, focusing on triple-negative breast cancer (TNBC). The last few months have been quite the journey! Please continue to refer to our shownotes to help navigate this complex disease treatment paradigm.

Episode 067: Breast Cancer Series, Pt. 12- A Patient's Perspective

We are not yet done with our breast cancer series, but we could not wait to share this incredibly personal conversation with a patient with a recent breast cancer diagnosis. This week, we sit down with Kaele Leonard, who herself is a Pulmonary/Critical Care fellow at Vanderbilt University Medical Center who was diagnosed with breast cancer in her early 30s.

As physicians, we don’t always get to hear what the journey through diagnosis, treatment, and follow up looks like from a patient’s perspective. We are so grateful to Dr. Leonard for opening up about this with us.

Episode 066: Breast Cancer Series, Pt. 11-Metastatic HER2+ Breast Cancer

This week, we continue our discussion about metastatic breast cancer, focusing on HER2+ disease.

Episode 065: Breast Cancer Series, Pt. 10-ER+, Metastatic Breast Cancer

After several weeks of covering localized disease, this week, we shift our discussion to metastatic breast cancer, focusing first on ER+ disease.

Episode 064: Breast Cancer Series, Pt. 9-Triple Negative, Early Stage Breast Cancer

This week, we round out our discussion on the early stage breast cancer, turning our attention to the triple negative subtype. Once again, there are a lot of trials and data, but be sure to check out the show notes for the highlights!

Episode 063: Breast Cancer Series, Pt. 8-HER2+, Early Stage Breast Cancer

We continue on our journey through early stage breast cancer, this time turning our attention to HER2+ disease. There is a lot of data in this episode, as you will both hear and see. To make this easier, we highlight key takeaways to make understanding this even easier.

Episode 062: “Paging Heme/Onc: Updates from ASCO 2023” - Management of NSCLC and KEYNOTE 671

This week’s episode is part 4 of 5 of a joint mini-series with our friends Two Onc Docs. In today’s episode, we will be recapping the current treatment of resectable NSCLC and discussing KEYNOTE 671, which was presented at ASCO 2023, looking at neoadjuvant chemo+immunotherapy followed by adjuvant immunotherapy. We also discuss the use of the “interaction test,” “multiplicity,” and it’s important role in understanding subgroup analyses.

Episode 061: “Paging Heme/Onc: Updates from ASCO 2023” - Classical Hodgkin’s Lymphoma and SWOG 1826

This week’s episode is part 2 of 5 of a joint mini-series with our friends Two Onc Docs. In today’s episode, we recap the current treatment of classical hodgkin’s lymphoma and then dive into the the SWOG 1826 plenary session abstract from the ASCO 2023 annual meeting. We also cover the concept of “p-values” and what it means when trials say “the median was not reached.”